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The NanoBio Science Partnership addresses critical needs in middle grade (6th-8th) science education in the Black Belt region, an area that has long been characterized as socioeconomically and educationally disadvantaged. The partnership provides professional development to 6th to 8th grade science teachers in order to shift their instruction from conventional teaching strategies to the use of an inquiry-centered approach in conjunction with the infusion of NanoBio science principles and 3-D simulations of concepts from their science curricula. Curriculum modules that support inquiry are being developed for use by the teachers and are tied to the middle grade science curricular objectives. The project also is recruiting and training prospective science teachers through the partnering universities' teacher preparation programs to provide them with an appropriately challenging and contemporary science curricula and teacher education foundation.